Towards Symmetric Thioamides: Microwave-Aided Synthesis of Terephthalic Acid Derivatives

The multistep synthesis of novel bis-terephthalthioamides based on methyl esters amino acids (AAs) was proposed using conventional heating and microwave-assisted approaches. In fact, the comparative case study thionation new symmetrical diamides with Lawesson’s reagent (LR) performed. microwave-accelerated small-scale methodology successfully employed whole pathway from substrates (Gly, Ala, Val, Tyr, Ser) to products (symmetrical dithioamides terephthalic acid), resulting in significantly reduced reaction time, energy requirements, slightly increased yields when compared heating. Moreover, intermolecular similarity acid derivatives estimated multidimensional space (mDS) structure/property-related silico descriptors principal component analysis (PCA) hierarchical clustering (HCA). distance-oriented structure/property distribution also correlated experimental lipophilic data.